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Key points: On average, Wegovy supports weight loss of around 15% after one year, while orlistat supports around 8% Theoretically, combining the two medications could support more weight loss as they work differently in the body, but as no research has been conducted in this area we simply dont know what the impact would be 3) Key considerations if taking Wegovy with orlistat Wed recommend speaking with your doctor or prescribing pharmacist before taking Wegovy and orlistat together so they can continue to monitor your progress and vital blood markers

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The patient should be apprised of the potential hazard to the embryo or fetus, and increased fetal monitoring might be warranted if exposure occurred

Insulin resistance & prediabetes, National Institute of Diabetes and Digestive and Kidney Diseases (2025) Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial, The Lancet Diabetes & Endocrinology (2024) With prediabetes, action is the best medicine, American Diabetes Association Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes2025, Diabetes Care (2025) About the Lifestyle Change Program, CDC (2024)

If you have diabetes, work with a healthcare provider who understands both your condition and peptide therapy